Compression-Coated Tablet for Colon Targeting: Impact of Coating and Core Materials on Drug Release
نویسندگان
چکیده
منابع مشابه
Compression of coated drug beads for sustained release tablet of glipizide: formulation, and dissolution.
A promising glipizide formulation comprising compression of four-layer coated beads into tablets was prepared. The tablet offered the advantages of: a two-hour lag time before drug release, retaining sustained release characteristics and providing approximately zero-order drug release. Drug release was nearly independent of paddle speeds of 50 and 100 rpm releasing 80% over 14 h similar to the ...
متن کاملDevelopment and Evaluation of Microbial Degradation Dependent Compression Coated Secnidazole Tablets for Colonic Delivery
The present paper describes development of a polysaccharide based compression coated tablets of secnidazole for colon delivery. Core tablet containing secnidazole was compression coated with various proportions of guar gum, xanthan gum and chitosan, either alone or in combinations. Drug release studies were performed in simulated gastric fluid (SGF) for 2 h followed by simulated intestinal flui...
متن کاملCompression Coated Tablets as Drug Delivery System (tablet in Tablet ) : a Review
Tablets are the most preferred and widely used dosage form because of their ease of administration, lower cost of manufacture, and elegance. So in this article, we describe the general characteristics, introduction,classification and formulation consideration of compression coating tablet. The compressioncoating granulation or blend can be preformulated to provide desired functionalities to the...
متن کاملDesign and Evaluation of Extended release tablet of Venlafaxine Hydrochloride using Compression coating method
Venlafaxine Hcl is an anti-depressant drug which is used in depression. The aim of present investigation was to prepare an ER tablet of Venlafaxine Hcl with similar dissolution profile matching to Effexor ER. An immediate release core tablet of 100mg was prepared and it was compression coated using HPMC matrix system. HPMC of three viscosity grades i.e., K4M, K15M, K100M and different concentra...
متن کاملImpact of compression pressure on tablet appearance.
The color of model tablets deepened and tablet gloss increased with increase in compression pressure regardless of colorant type. The possible reasons for these phenomena were examined. These observations could not be explained either by polymorphic transition of the colorant or by condensation of the colorant during compression. Instead, a change in surface roughness was assumed to be the most...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2015
ISSN: 1530-9932
DOI: 10.1208/s12249-015-0359-0